Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection. |
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| Authors: | M F Carlier A Ducruix D Pantaloni |
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| Affiliation: | Laboratoire d'Enzymologie et Biochimie Structurale, CNRS, 91198 Gif-sur-Yvette, France. carlier@lebs.cnrs-gif.fr |
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| Abstract: | The molecular link between the signalling pathway regulating the formation of filopodia and the initiation of local actin polymerization has been elucidated: N-WASP, a close homologue of WASP, which is the product of the gene responsible for the Wiskott-Aldrich syndrome, mediates a direct connection between the small G-protein Cdc42 and the Arp2/3 complex. |
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