Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor |
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| Authors: | Choi Mun Ju Chandra Girish Lee Hyuk Woo Hou Xiyan Choi Won Jun Phan Khai Jacobson Kenneth A Jeong Lak Shin |
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| Institution: | Laboratory of Medicinal Chemistry, College of Pharmacy and Department of Bioinspired Science, Ewha Womans University, Seoul, 120-750, Korea. |
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| Abstract: | The stereoselective synthesis of truncated 3'-aminocarbanucleosides 4a-d via a stereo- and regioselective conversion of a diol 9 to bromoacetate 11a and their binding affinity towards the human A(3) adenosine receptor are described. |
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