Biologically active heterocyclic analogs of thiourea (review)

The results of research carried out in the Scientific-Research Institute of Medicinals (Budapest, Hungary) are correlated. The structures of 2-aminothiazolines, which can exist in the tautomeric 2-iminothiazolidine form, and of the corresponding analogs of the thiazine series and their acyl derivatives are discussed. A new method for the synthesis of 3-aryl-substituted 2-iminothiazolidines and 2-iminoperhydro-1,3-thiazines is examined. Data on the biological activity of some of the investigated compounds are presented.For example, it is known that 2-(octahydro-1-azocinyl)ethylguanidine (guanethidine) has excellent antihypertensive properties 6–8].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 878–888, July, 1978.