The Robert Robinson Laboratories, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, England
Abstract:
The synthesis of the (105–117) fragment of a Lysozyme analogue is described. This sequence was assembled by DCCl/HONSu fragment coupling of the (105–111) and (112–117) subfragments which were both constructed by the fragment coupling method. The arginine residue at position 114 was initially unprotected but ultimately protection was afforded by the use of the adamantyloxycarbonyl group.