Synthèse d'analogues de dérivés dioxaprostanoïques à partir du d et du l-xylose |
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Authors: | L Castellanos A Gateau-Olesker F Panne-Jacolot J Cleophax SD Gero |
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Institution: | Institut de Chimie des Substances Naturelles, CNRS, 91190 Gif sur Yvette, France |
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Abstract: | Epoxides 7, 8 and 9 have been prepared from d and l-xylose, and used for the synthesis of a precursor of ent-(11-oxa)PG 19 and of 9,13-and 7,11-dioxaprostanoïc acids 28 and 31. The site of the opening of the epoxidcs 7 and 9 with the carbanion derived from bis-(phenylth)romethane and with LiAlH4 is shown by establishing structures of the products 11, 12, 20 et 21 by 13CNMR spectroscopy. |
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