The Robert Robinson Laboratories, University of Liverpool, PO Box 147, Liverpool, L69, 3BX, England
Abstract:
The synthesis of the (118–129) fragment of a Lysozyme analogue was achieved by the fragment coupling approach. The fragments were assembled using the DCCI/HONSu method and the (118–122), (123–126) and (127–129) subfragments were each built up in a stepwise manner. At several stages the diphenylphosphinic mixed anhydride method was found to be superior to the pivalic mixed anhydride method.