Construction of polycyclic spiro-indolines via an intramolecular oxidative coupling/cyclization cascade reaction process |
| |
Authors: | Fan Feng Xie Weiqing Ma Dawei |
| |
Affiliation: | School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. |
| |
Abstract: | An efficient protocol for assembling a polycyclic spiroindoline scaffold is developed, which involves an intramolecular oxidative coupling of dianions derived from indole-embodied β-ketoamides using iodine as the oxidant, and subsequent attack of oxygen anion to the resultant imine moiety. A number of tetracyclic spiroindolines are prepared with moderate to good yields. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|