Syn-selective vinylogous Kobayashi aldol reaction |
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Authors: | Symkenberg Gerrit Kalesse Markus |
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Institution: | Institut für Organische Chemie and Centre of Biomolecular Drug Research (BMWZ), Leibniz Universit?t Hannover, Schneiderberg 1B, 30167 Hannover, Germany. |
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Abstract: | The Kobayashi aldol reaction has become a prominent transformation in polyketide syntheses. This methodology takes advantage of the directing effects of the Evans auxiliary and allows the stereoselective incorporation of a four carbon segment with two additional methyl branches establishing an anti-relationship between the two newly formed chiral centers. So far this transformation was restricted to anti-aldol products. We present here a modified protocol that provides the corresponding aldol product with high syn-selectivity. |
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