Intramolecular carbolithiation reactions for the preparation of 3-alkenylpyrrolidines |
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| Authors: | Coldham Iain Price Kathy N Rathmell Richard E |
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| Institution: | School of Chemistry, University of Exeter, Stocker Road, Exeter, UK EX4 4QD. i.coldham@ex.ac.uk |
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| Abstract: | Tin-lithium exchange allows the formation of alpha-amino-organolithium species that undergo anionic cyclization onto allylic ethers to give 3-alkenylpyrrolidines. The methodology has been applied to the synthesis of an advanced intermediate related to the natural product (-)-alpha-kainic acid. |
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