Effects of beta-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP(81-145) |
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| Authors: | Oishi Takehisa Hagiwara Ken-ichi Kinumi Tomoya Yamakawa Yoshio Nishijima Masahiro Nakamura Kazuhiko Arimoto Hirokazu |
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| Institution: | Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan. |
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| Abstract: | The effects of Soto's 'beta-sheet breaker peptide' and its polymer on PrPSc formation in ScN2a cells were investigated. Surface plasmon resonance study indicated that direct binding between PrP(81-145) and the 'beta-sheet breaker peptide' is not specific and may not play a major role in the inhibition of PrPSc formation. |
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