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Conformational analysis by HRMAS NMR spectroscopy of resin-bound homo-peptides from C(alpha)-methyl-leucine |
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| Authors: | Rainaldi Mario Lancelot Nathalie Elbayed Karim Raya Jesus Piotto Martial Briand Jean-Paul Kaptein Bernard Broxterman Quirinus B Berkessel Albrecht Formaggio Fernando Toniolo Claudio Bianco Alberto |
| Affiliation: | Institute of Biomolecular Chemistry, CNR, Department of Organic Chemistry, University of Padova, 35131 Padova, Italy. |
| Abstract: | A series of [L-(alphaMe)Leu]n (n = 1-5) homo-peptides have been covalently linked to Tentagel and POEPOP resins and submitted to a conformational study using HRMAS NMR spectroscopy. Whereas the mono- and dipeptide are mainly fully-extended, stable 3(10)-helical structures are formed beginning from the trimer. |
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