Potent and specific sialyltransferase inhibitors: imino-linked 5a'-carbadisaccharides |
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| Authors: | Okazaki Kensuke Nishigaki Sachiko Ishizuka Fumito Kajihara Yasuhiro Ogawa Seiichiro |
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| Affiliation: | Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan. |
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| Abstract: | Methyl 5a'-carba-beta-lactoside, imino-linked, has been shown to possess potent and specific inhibitory activity (IC50 = 185 microM) toward rat recombinant alpha2,3-sialyltransferase. |
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