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| Inclusion Complex of Paclitaxel in Hydroxypropyl-β-cyclodextrin | |
| 引用本文： | CHEN Yue ZHOU Yu-lai REN Yong YAN Wei-qun. Inclusion Complex of Paclitaxel in Hydroxypropyl-β-cyclodextrin[J]. 高等学校化学研究, 2005, 21(6): 749-752 |
| 作者姓名： | CHEN Yue ZHOU Yu-lai REN Yong YAN Wei-qun |
| 作者单位： | [1]College of Pharmaceutical, Jilin University, Changchun 130021, P. R. China [2]Institute of Frontier Medical Science, Jilin University, Changchun 130021, P. R. China [3]Center of Drug Discovery, Nanfing Normal University, Nanfing 210097, P. R. China |
| 基金项目： | Supported by the Scientific and Technological Development Program Foundation of Jilin Province （No. 2005106）. |
| 摘 要： | Introduction Paclitaxel （as Taxol） is a kind of diterpenoid natural product extracted from Chinese yew. It has been reported to have high anti-tumor effects, such as the activity against oophorama, mammary cancer, encephaloma, cervical carcinoma, and non- small-cell lung carcinoma. One of the major problems of paclitaxel applied to therapy is its extremely low solubility in water. In addition, paclitaxel is administered as a slow infusion in a vehicle consisting of Cremophor EL （ polyoxyethylated castor oil ）. However, Cremophor has been observed to cause severe, occasionally fatal hypersensitivity reactions in animals and humans. Therefore, paclitaxel therapy includes a prophylactic regimen of antihistamines and corticosteroids , along with a prolonged infusion time to reduce the severity and incidence of hypersensitivity reactions. Because of the reasons mentioned above, currently its preparation needs to be improved further. |
| 关 键 词： | 环式糊精 紫杉酚 生物活性 超敏性 |
| 文章编号： | 1005-9040（2005）-06-749-04 |
| 收稿时间： | 2005-03-21 |
Inclusion Complex of Paclitaxel in Hydroxypropyl-β-cyclodextrin |
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| CHEN;Yue;ZHOU;Yu-lai;REN;Yong;YAN;Wei-qun. Inclusion Complex of Paclitaxel in Hydroxypropyl-β-cyclodextrin[J]. Chemical Research in Chinese University, 2005, 21(6): 749-752 | |
| Authors: | CHEN Yue ZHOU Yu-lai REN Yong YAN Wei-qun |
| Affiliation: | 1. College of Pharmaceutical, Jilin University, Changchun 130021, P. R. China; 2. Institute of Frontier Medical Science, Jilin University, Changchun 130021, P. R. China; 3. Center of Drug Discovery, Nanjing Normal University, Nanjing 210097, P. R. China |
| Abstract: | |
| Keywords: | Paclitaxel HP-β-CD Inclusion comp lex Combinative ratio |
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