Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys
obcordata and Their Antinephrolithiasis Activity |
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| Authors: | Zhaocui Sun Meiying Chen Qinglong Li Guoxu Ma Haifeng Wu Junshan Yang Yihang Li Xudong Xu |
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| Affiliation: | 1.Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, China; (Z.S.); (M.C.); (Q.L.); (G.M.); (H.W.); (J.Y.);2.Yunnan Branch, Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Jinghong 666100, China |
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| Abstract: | From the dried vines of Aspidopterys obcordata Hemsl, five new polyoxypregnane glycosides, named obcordatas J–N (1–5), were obtained. Their structures were fully elucidated and characterized by HRESIMS and extensive spectroscopic data. In addition, all of the new compounds were screened for their antinephrolithiasis activity in vitro. The results showed that compounds 1–3 have prominent protective effects on calcium oxalate crystal-induced human kidney 2 (HK-2) cells, with EC50 values ranging from 6.72 to 14.00 μM, which is consistent with the application value of A. obcordata in folk medicine for kidney stones. |
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| Keywords: | Aspidopterys obcordata polyoxypregnane glycosides antinephrolithiasis HK-2 cells |
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