Putting a lid on protein folding: structure and function of the co-chaperonin,GroES |
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| Affiliation: | 1. Department of Genetics, School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA;2. Howard Hughes Medical Institute, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA |
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| Abstract: | The co-chaperonin GroES is an essential partner in protein folding mediated by the chaperonin, GroEL. Two recent crystal structures of GroES provide a structural basis to understand how GroES forms the lid on the folding-active cis ternary complex, and how the GroEL-GroES complex enhances folding. |
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