| 底物,水量对脂肪酶不对称拆分萘普生的影响 |
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| 引用本文： | 徐毅 李树本. 底物,水量对脂肪酶不对称拆分萘普生的影响[J]. 分子催化, 1999, 13(4): 292-296 |
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| 作者姓名： | 徐毅 李树本 |
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| 作者单位： | 中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室!兰州730000，中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室!兰州730000，中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室!兰州730000，中国科学院兰州化学物理研究所羰基合成与 |
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| 基金项目： | 中国科学院重点项目,中国科学院西部之光项目 |
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| 摘 要： | 选择了一种便于底物－产物分离的微水－有机两相体系，将对Ｓ－（＋＿萘普生酯有高度对映体选择性的ＣＣＬ脂肪酶固定于硅藻土上。合成了了一种能提高酶催化反应速度的激活的酯－萘普生氯乙酯。
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| 关 键 词： | 萘普生氯乙酯 非甾体 抗炎类药物 水量 |
Influence of Substrate and Water Amount on the Asymmetric Resolution of Naproxen by Lipase |
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| XU Yi,LI Shu|ben,XIN Jia|ying,WANG Lai|lai,SHEN Run|nan,YU Chi|li. Influence of Substrate and Water Amount on the Asymmetric Resolution of Naproxen by Lipase[J]. Journal of Molecular Catalysis (China), 1999, 13(4): 292-296 |
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| Authors: | XU Yi LI Shu|ben XIN Jia|ying WANG Lai|lai SHEN Run|nan YU Chi|li |
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| Abstract: | A kind of microaqueous|organic two phase system was selected for the resolution of Naproxen. CCL(Candida cylindracea lipase)with high enantioselectivity for Naproxen ester was immobilized on celite by adsorption. Naproxen chloroethyl ester as an actived ester had been synthesized and used to enhance the rate of hydrolysis catalyzed by CCL, and the conversion of which reached 35% after 24 h reaction. The reaction rate of this actived ester is far more rapid than naproxen methyl ester. Inhibition appeared when the concentration of naproxen chloroethyl ester is too high. The influence of water amount on reaction catalyzed by enzyme was briefly discussed. The reaction rate is the largest when water has a monolayer distribution on the surface of carrier. |
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| Keywords: | Naproxen chloroethyl ester Asymmetric resolution Water amount Microaqueous|organic two phase system |
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