Inhibiting effect of 6-methyluracil derivatives on the free -radical oxidation of 1,4-dioxane

The antioxidation activity of 5-substituted 6-methyluracils was quantitatively estimated in the model system of initiated radical-chain oxidation of 1,4-dioxane. The rate constants of the reactions of 1,4-dioxane peroxide radicals with 6-methyluracil (1), 6-methyl-5-piperidinouracil (2), 6-methyl-5-morpholinomethyluracil (3), 6-methyl-5-morpholinouracil (4), 6-methyl-5-methylaminouracil (5), 5-ethylamino-6-methyluracil (6), and 5-hydroxy-6-methyluracil (7) were measured. Among compounds 1–7, derivative 7 is most efficient with an inhibition rate constant of (5.2±0.1) · 10⁴ L mol^-1 s^-1 (60 °C).