ZUM WIRKUNGSMECHANISMUS PHOTODYNAMISCHER FUROCUMARINE PHOTOREAKTION VON PSORALEN-(4-14C) MIT DNS, RNS, HOMOPOLYNUCLEOTIDEN UND NUCLEOSIDEN |
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| Authors: | C H Krauch D M Krämer A Wacker |
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| Institution: | Institut für Therapeutische Biochemie der Universität Frankfurt am Main und Max-Planck-Institut für Kohlenforschung, Abt. Strahlenchemie, Mülheim-Ruhr |
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| Abstract: | Abstract— The photodynamic binding of psoralen to DNA and RNA was shown using different methods. This binding was found to be mainly located either at thymine or uracil. The concentration and pH dependancy was studied. The photoproduct obtained with uridine was isolated paper chromatographically and was split into initial components photochemically.
The results bring an evidence that psoralen with its 3,4-double bond is able to form a cyclic derivative with the C6-C6 doble bond of thymine or uracil. |
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