| 实体肿瘤血管生成和肿瘤生长的耦合研究 |
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| 引用本文： | 赵改平,许世雄,陈二云,沈力行,郦鸣阳,吴洁. 实体肿瘤血管生成和肿瘤生长的耦合研究[J]. 力学季刊, 2008, 29(4) |
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| 作者姓名： | 赵改平 许世雄 陈二云 沈力行 郦鸣阳 吴洁 |
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| 作者单位： | [1]上海理工大学医疗器械与食品学院,上海200093 [2]复旦大学力学与工程科学系,上海200433 [3]南京理工大学机械工程学院,南京210094 |
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| 基金项目： | 国家自然科学基金 ， 上海高校选拔培养优秀青年教师科研专项基金 ， 博士科研启动费基金 |
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| 摘 要： | 研究宏观尺度上肿瘤向外浸润式生长的动态变化对微观尺度上肿瘤内部微血管网生成过程产生的影响。建立肿瘤组织生长动力学模型与促血管生成的二维离散数学模型，模型考虑促血管生成因子诱导下血管内皮细胞的随机性、趋化性和趋触性运动以及血管内皮细胞与胞外基质的相互作用，并且肿瘤组织的生长满足经典的Compertz函数形式，通过耦合研究模拟了肿瘤组织动态生长过程中微脉管系统生成的时空演化，数值生成肿瘤动态生长下内外异构的微血管网和肿瘤内部分层的网络结构。该模型可以产生相对真实的具有接近肿瘤病理生理特性的血管网，为临床研究提供有益的信息。
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| 关 键 词： | 实体肿瘤 血管生成 肿瘤生长 耦合研究 |
Coupled Study of Tumor Induced Angiogenesis and Tumor Growth |
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| ZHAO Gai-ping,XU Shi-xiong ,CHEN Er-yun,SHEN Li-xing,LI Ming-yang,WU Jie. Coupled Study of Tumor Induced Angiogenesis and Tumor Growth[J]. Chinese Quarterly Mechanics, 2008, 29(4) |
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| Authors: | ZHAO Gai-ping XU Shi-xiong CHEN Er-yun SHEN Li-xing LI Ming-yang WU Jie |
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| Affiliation: | 1.School of Medical instrument;Shanghai University of Science and Technology;Shanghai 200093;China;2.Department of Mechanics and Engineering Science;Fudan University;Shanghai 200433;3.School of Mechanical Engineering;Nanjing University of Science and Technology;Nanjing 210094;China |
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| Abstract: | The tumor induced angiogenesis was investigated under the influence posed by tumor dynamic growth.A coupled "macroscopical tumor dynamic growth-microscopic vascular network formation" mathematical model was built to simulate physiological process of tumor induced angiogenesis.The model assumes that the endothelial cells migrate through random motility,chemotaxis and haptotaxis in the extracellular matrix,and the tumor growth complies with previously classical Compertz function.The simulation results show th... |
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| Keywords: | solid tumor angiogenesis tumor growth coupled study |
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