A novel, efficient, diastereo- and enantioselective Mukaiyama aldol-based synthesis of a vinyl cyclopentanone core derivative of viridenomycin |
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| Authors: | Batsanov Andrei S Knowles Jonathan P Lightfoot Andrew P Maw Graham Thirsk Carl E Twiddle Steven J R Whiting Andrew |
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| Affiliation: | Department of Chemistry, Durham University, Science Laboratories, South Road, Durham DH1 3LE, UK. |
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| Abstract: | A strategy has been developed for a rapid seven-step construction of a chiral, nonracemic vinyl cyclopentanone building block as part of a synthetic approach to viridenomycin, using a diastereo- and enantioselective Mukaiyama aldol and intramolecular Knoevenagel condensation as key steps. |
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