In vivo estimation of relaxation processes in benign hyperplasia and carcinoma of the prostate gland by magnetic resonance imaging |
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| Authors: | L Kjaer C Thomsen P Iversen O Henriksen |
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| Affiliation: | 1. Department of Magnetic Resonance, Hvidovre Hospital, University of Copenhagen, Denmark;2. Department of Urology, Hvidovre Hospital, University of Copenhagen, Denmark;2. Heidelberg University Medical School, Heidelberg, Germany;1. CNR – IAC, Roma, Italy;2. Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, University “G. d’Annunzio” of Chieti-Pescara, Italy;3. INRIA Sophia Antipolis – Mediterranee, France;4. Brown University, USA;5. Department of Mathematics, University of Genova, Italy;6. CNR – SPIN, Genova, Italy;1. The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China;2. Department of Hydraulic Engineering, School of Civil Engineering, Tsinghua University, Beijing 100084, China;3. Jinling Hospital, Nanjing 210002, Jiangsu, China;4. Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035 Chengdu, China;5. School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, China;1. Department of Radiation Oncology, Baskent University, Faculty of Medicine Adana Dr Turgut Noyan Research and Treatment Center, Adana, Turkey;2. Department of Radiation Oncology, Baskent University Faculty of Medicine, Ankara, Turkey;3. Department of Radiology, Baskent University Faculty of Medicine Adana Dr Turgut Noyan Research and Treatment Center, Adana, Turkey;4. Division of Radiation Oncology, Iskenderun Gelisim Hospital, Hatay, Turkey |
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| Abstract: | Tissue characterization for separating malignant from benign tissue is a clinically very important potential of magnetic resonance imaging (MRI). In this study quantitative determination of T1- and T2-relaxation processes was accomplished in five healthy volunteers, 10 patients with benign hyperplasia of the prostate gland and eight patients with prostatic carcinoma. Histological verification was obtained in all the patients. The measurements were performed on a wholebody MR-scanner operating at 1.5 T using six inversion recovery sequences (TR = 4000 msec) for T1-determination and a 32 spin-echo sequence (TR = 3000 or 2000 msec) for T2-estimation. The T1-relaxation curves all appeared monoexponential, whereas the T2-curves in most cases showed a multiexponential behaviour. A considerable overlap of the relaxation curves was seen. Consequently, we found no statistically significant differences between the T1- or the T2-relaxation times of the three groups investigated. It is concluded that tissue characterization based on relaxation time measurements with MRI does not seem to have a clinically useful role in prostatic disease. |
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