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Absolute stereochemistry of securinine |
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| Authors: | Z Horii M Ikeda Y Yamawaki Y Tamura S Saito |
| Institution: | School of Pharmacy, Osaka University, Toneyama, Toyonaka, Osaka, Japan Osaka Research Laboratory, Tanabe Seiyaku Co. Ltd. Kashima-cho Higashiyodogawa-ku, Osaka, Japan |
| Abstract: | The absolute configuration of securinine was shown to be I from the rotatory dispersion curves and molecular rotations of degradation products of securinine. The conclusion was unequivocally confirmed by the formation of (+)-N-benzoylpipecolic acid on degradation of this alkaloid. The conformation of the bridgehead nitrogen was also discussed. |
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