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New Supramolecular Drug Carriers: The Study of Organogel Conjugated Gold Nanoparticles |
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| Authors: | Joanna Kowalczuk Andrzej &#x;api&#x;ski Elbieta Stolarczyk Oleg M Demchuk Konrad Kubi&#x;ski Monika Janeczko Aleksandra Martyna Maciej Mas&#x;yk Sylwia Turczyniak-Surdacka |
| Institution: | 1.Institute of Molecular Physics, Polish Academy of Sciences, 60-179 Poznan, Poland;2.Łukasiewicz Research Network, Institute of Industrial Chemistry, 01-793 Warsaw, Poland;3.Department of Molecular Biology, Faculty of Science and Health, The John Paul II Catholic University of Lublin, 20-708 Lublin, Poland; (K.K.); (M.J.); (A.M.); (M.M.);4.Biological and Chemical Research Centre, University of Warsaw, 02-089 Warsaw, Poland; |
| Abstract: | An aqueous solution of sodium citrate stabilized gold nanoparticles (AuNP) in the presence of N-lauroyl-L-alanine (C12ALA) forms a stable gel. The structure of the gel and the distribution profile of AuNP in it were analyzed. Will nanoparticles separated from each other with sodium citrate behave in the same way in solution and trapped in the gel matrix? Will the spatial limitation of solvent molecules aggregate nanoparticles and destroy their homogeneity? These questions are very important from the point of view of the use of gold nanoparticles, trapped in the gel structure as carriers of drugs in the slow-release process. The lack of homogeneity of this distribution will have a major impact on the rate of release of the appropriate amount of therapeutic drug from the matrix. In this work, we attempt to answer these questions. The performed biological assays revealed that both C12ALA and C12ALA-AuNP show an excellent level of biological neutrality. They might be used as a transporting medium for a drug delivery without affecting the drug’s activity. |
| Keywords: | pharmaceutical gels gold nanoparticles SEM Raman spectrometry diffusiometry TGA biological activity |