Composition,Anti-MRSA Activity and Toxicity of Essential Oils from Cymbopogon Species |
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| Authors: | Bart&#x;omiej Piasecki Anna Biernasiuk Adrianna Skiba Krystyna Skalicka-Wo
niak Agnieszka Ludwiczuk |
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| Institution: | 1.Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 20-093 Lublin, Poland;2.Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland;3.Department of Natural Products Chemistry, Medical University of Lublin, 20-093 Lublin, Poland; (A.S.); (K.S.-W.) |
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| Abstract: | Many of the essential oils obtained from medicinal plants possess proven antimicrobial activity and are suitable for medicinal purposes and applications in the food industry. The aim of the present work was the chemical analysis of 19 essential oils (EOs) from seven different Cymbopogon species (C. nardus, C. citratus, C winterianus, C. flexuosus, C. schoenanthus, C. martinii, C. giganteus). Five different chemotypes were established by GC/MS and TLC assay. The EOs, as well as some reference compounds, i.e., citronellol, geraniol and citral (neral + geranial), were also tested for their antimicrobial and antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) by the microdilution method and direct bioautography. The toxicity of EOs was evaluated by Danio rerio ‘Zebrafish’ model assay. All examined EOs showed moderate to high activity against MRSA, with the highest activity noted for C. flexuosus—lemongrass essential oil, both in microdilution and direct autobiography method. Significant difference in the toxicity of the examined EOs was also detected. |
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| Keywords: | Cymbopogon TLC-bioautography antibiofilm activity essential oil zebrafish GC/MS |
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