Chiral ligand exchange chromatography on polygalactomannan (Guaran) |
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Authors: | R Mathur S Bohra V Mathur C K Narang N K Mathur |
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Institution: | (1) Department of Chemistry, University of Jodhpur, 342 001 Jodhpur, India |
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Abstract: | Summary The Chiral discriminating properties of the legume seed (Cyamopsis tetragonalobus) polysaccharide, guaran, has been investigated by this laboratory. Due to the presence of cis-hydroxyl groups in its molecule, guaran a galactomannan, forms tetracoordinated polymeric complexes with boron, resulting in cross-linking and gelling. Ligand exchange between the polymeric boron complex and a low molecular weight chiral diol can take place with stereoselectivity. The principle has been applied for the resolution of (±) mandelic acid by using ligand exchange chromatography. |
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Keywords: | Column liquid chromatography Chiral discrimination Guaran-borate complex Mandelic acid enantiomers |
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