a Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China;b Drug Evaluation Center of State Food and Drug Administration, Beijing 100038, China
Abstract:
Mycobacterium tuberculosis FabH,an essential enzyme in mycolic acids biosynthetic pathway,is an attractive target for novel anti-tuberculosis agents.Structure-based design,synthesis of novel inhibitors of mtFabH was reported in this paper.A novel scaffold structure was designed,and 12 candidate compounds that displayed favorable binding with the active site were identified and synthesized.