Diversity-oriented synthesis of 3-iodochromones and heteroatom analogues via ICl-induced cyclization |
| |
Authors: | Zhou Chengxiang Dubrovsky Anton V Larock Richard C |
| |
Institution: | Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA. |
| |
Abstract: | The ICl-induced cyclization of heteroatom-substituted alkynones provides a simple, highly efficient approach to various 3-iodochromones and analogues. This process is run under mild conditions, tolerates various functional groups, and generally provides chromones in good to excellent yields. Subsequent palladium-catalyzed transformations afford a rapid increase in molecular complexity and a convenient preparation of a wide range of functionally substituted chromones, furans, and polycyclic compounds. Iodothiochromenones and iodoquinolinones are also prepared by similar ICl-induced cyclizations. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|