| Total Synthesis of (±)-Nocardione A and (±)-Nocardione B, Two Cdc25B Tyrosine Phosphatase Inhibitors |
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| 作者姓名： | Hai YANG Wei LU* Jian Xiong BAO Haji Aker AISA Jun Chao CAI Shanghai Institute of Materia Medica SIBS Chinese Academy of Sciences Shanghai Xinjiang Institute of Chemistry Chinese Academy of Sciences Urumqi |
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| 作者单位： | Hai YANG1，2，Wei LU1*，Jian Xiong BAO1，Haji Aker AISA2，Jun Chao CAI1 1Shanghai Institute of Materia Medica，SIBS，Chinese Academy of Sciences，Shanghai 200031 2Xinjiang Institute of Chemistry，Chinese Academy of Sciences，Urumqi 830011 |
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| 基金项目： | We thank theNationalNaturalScienceFoundation ofChina[20002005] for financial supports. |
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| 摘 要： | Quinones are biologically important compounds, especially because of their cytotoxic and pharmacological action. The antitumor activities of the quinones, including naphthoquinones1, were revealed more than two decades ago when the National Cancer Institute published a report in which 1500 synthetic and nature quinones were screened. Some natural naphthoquinones were under development for antitumor agents2. The protein tyrosine phosphatases (PTPase) and dual phosphatases (DSPase) are key…
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