Preparation and application of mesoporous core-shell nanosilica using leucine derivative as template in effective drug delivery |
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| Institution: | 1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;2. School of Life Science & Bio-pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China;1. Jiangnan University, Wuxi 214122, PR China;2. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China;1. School of Chemistry and Chemical Engineering, Xi’an University of Arts and Science, Xi’an 710065, Shaanxi, People’s Republic of China;2. School of Materials Science and Engineering, Shaanxi Normal University, Xi’an 710062, Shaanxi, People’s Republic of China;1. Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States;2. Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110122, China;3. State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China;1. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China;2. College of Life Science, Jiangxi Normal University, Nanchang 330031, China;1. Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore;2. Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskölds väg 20, Uppsala Se-751 85, Sweden;3. Institute of Radiochemistry and Radioecology, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, Hungary;4. Department of Biophysics and Radiation Biology, Semmelweis University Faculty of Medicine, T?zoltó u. 37-47, Budapest H-1094, Hungary |
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| Abstract: | Core-shell structured mesoporous silica nanoparticles have been firstly synthesized with the new template from L-leucine methyl ester hydrochloride (H-Leu-OMe·HCl). LMSNs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, and small-angle X-ray diffraction (SAXRD), demonstrating a well-ordered mesostructure. After loading doxorubicin hydrochloride (Dox) into pores, considerable loading capacity of 30.5% and favorable cumulative release amount were obtained. MTT assay suggested that Dox-loaded LMSNs demonstrated great promise to anti-tumor. The use of MSNs with the synthesized template, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials. |
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| Keywords: | Core-shell structure Mesoporous silica nanoparticles Biomimetic method Template synthesis Self-assembly |
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