LHRH/TAT dual peptides-conjugated polymeric vesicles for PTT enhanced chemotherapy to overcome hepatocellular carcinoma |
| |
| Institution: | 1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;2. Department of Pediatrics, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing 100029, China;3. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China;4. Shanghai Research Institute of Fragrance and Flavor Industry, Shanghai 200232, China;5. School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 200233, China;1. College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China;2. College of Chemical Science and Technology, Yunnan University, Kunming 650091, China;1. Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China;2. Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;1. State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Polytechnic University, Tianjin 300387, China;2. Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China |
| |
| Abstract: | Combination therapy such as photothermal therapy (PTT) enhanced chemotherapy is regarded as a promising strategy for cancer treatment. Herein, we developed redox-responsive polymeric vesicles based on the amphiphilic triblock copolymer PCL-ss-PEG-ss-PCL. To avoid the limited therapeutic effect of chemotherapeutic drugs caused by systemic exposures and drug resistance, the redox-sensitive polymeric vesicles were cargoed with two chemotherapeutics: doxorubicin (DOX) and paclitaxel (PTX). Besides, indocyanine green (ICG) was encapsulated, and cell-penetrating peptides and LHRH targeting molecule were modified on the surface of polymeric vesicles. The results indicated that the polymeric vesicles can load different kinds of drugs with high drug loading content, trigger drug release in responsive to the reductive environment, realize high cellular uptake via dual peptides and laser irradiation, and achieve higher cytotoxicity via chemo-photothermal combination therapy. Hence, the redox-responsive LHRH/TAT dual peptides-conjugated PTX/DOX/ICG co-loaded polymeric micelles exhibited great potential in tumor-targeting and chemo-photothermal therapy. |
| |
| Keywords: | Redox-responsive Polymeric vesicles Chemotherapy Photothermal therapy Combination therapy |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
