Diastereoselective synthesis of functionalized tetrahydro-γ-carbolines via a[3+3] cycloaddition of 2,2’-diester aziridines with β-(indol-2-yl)-α,β-unsaturated ketones |
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作者姓名: | Xuejie Zou Yangzi Liu Shaojing Shang Wulin Yang Weiping Deng |
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作者单位: | Shanghai Key Laboratory of New Drug Design and School of Pharmacy |
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基金项目: | supported by the National Natural Science Foundation of China(No.21772038);the China Postdoctoral Science Foundation(No.2018M632037)。 |
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摘 要: | A Sc(OTf)3-catalyzed[3+3]cycloaddition of 2,2’-diester aziridines withβ-(indol-2-yl)-α,β-unsaturated ketones was developed,affording polysubstituted tetrahydro-y-carbolines in single diastereoisomers in good to excellent yields.
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关 键 词: | AZIRIDINE Tetrahydro-γ-carboline [3+3]cycloaddition Sc(OTf)3 DIASTEREOSELECTIVITY |
收稿时间: | 2019-07-30 |
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