Anti-inflammatory catecholic chitosan hydrogel for rapid surgical trauma healing and subsequent prevention of tumor recurrence |
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| Institution: | 1. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China;2. School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China;3. School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, China;1. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China;2. Engineering Research Center of Biochemistry of Agricultural Products, Ministry of Education, Hefei University of Technology, Hefei 230009, PR China;3. School of Biomedical Engineering, Anhui Medical University, Hefei 230032, PR China;4. Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR China;1. College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai 200093, PR China;2. Department of Gastroenterology, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, PR China;1. NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, PR China;2. School of Pharmacy, Nanjing Medical University, Nanjing 211166, PR China;3. Department of Pathology, Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, PR China;1. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China;2. Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory of Ultrasound Imaging and Therapy, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;3. Shenzhen Bay Laboratory, Shenzhen 518107, China;4. School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China;1. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China;2. Guangdong Pharmaceutical University, Guangzhou 510006, China;3. Institute of Pharmacy, Pharmaceutical College of Henan University, Kaifeng 475004, China |
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| Abstract: | Although occupying pillar position in clinical cancer treatments, surgery itself and surgical trauma would elicit series of local/systemic inflammation-related responses that resulted in high rate of tumor recurrence. Herein, chitosan with conjugated gallic acid (CSG) molecules were coordinated with Fe3+ to form CSG/Fe3+ hydrogel for filling the tumor-resected cavity with considerable wet-adhesion ability and anti-inflammatory performance. With the assistance of doxorubicin hydrochloride (DOX?HCl), CSG/Fe3+/DOX hydrogel exhibited synergistic photothermal-chemo tumor-inhibited performance under near-infrared (NIR) light irradiation for eradicating residual and/or surgical trauma-recruited cancer cells. Thus, our study attempts to show a paradigm that realizes quick surgical trauma healing, inflammation inhibition and prevention of postsurgical tumor recurrence. |
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| Keywords: | Surgery Anti-inflammation Bactericidal capacity Trauma healing Tumor recurrence |
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