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TFA promoted multi-component reaction of aryldiazonium with sodium metabisulphite and thiols: Construction of thiosulfonate under transition-metal free conditions
Institution:1. College of Chemistry and Materials Science, Hunan Agricultural University, Changsha 410128, China;2. School of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China;3. Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha 410114, China;1. College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China;2. School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China;3. College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China;1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;2. D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation;3. I. M. Sechenov First Moscow State Medical University, 119991 Moscow, Russian Federation
Abstract:A TFA promoted multi-component reaction of aryldiazonium with sodium metabisulphite and thiols to construct thiosulfonates under transition-metal free conditions is reported. The thiosulfonates were isolated in good yields with broad tolerance of functional group. Readily available inorganic Na2S2O5 was applied as the sulfur dioxide surrogate. This strategy features easily available substrates, mild reaction conditions and free transition-metal catalyst.
Keywords:Metal-free  Thiosulfonate  Sulfur dioxide  Sodium metabisulfite
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