A supramolecular co-delivery strategy for combined breast cancer treatment and metastasis prevention |
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Affiliation: | 1. School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, China;2. Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Weijin Road 92, Tianjin 300072, China;3. Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of People''s Armed Police Force, 220 Chenglin Road, Tianjin 300162, China;4. Department of Physiology and Pathophysiology, Logistics University of Chinese People''s Armed Police Force, Tianjin 300309, China;5. Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, China |
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Abstract: | We herein propose a co-delivery approach where small interference RNA (siRNA) and anticancer chemotherapeutic drug are simultaneously loaded into a single delivery carrier for the combined treatment of breast cancer and metastasis prevention. The co-delivery vector is composed of chondroitin sulfate (CS)-coated β-cyclodextrin-polyethylenemine polymer, which is capable of loading paclitaxel (PTX) and siRNA simultaneously to form therapeutic nanocomplexes. The nanocomplex, termed as CP-PTX-siCD146-CS, is demonstrated to have strong active targeting ability towards CD44-overexpresing breast cancer cells. Moreover, the co-delivery of PTX and siRNA not only effectively inhibits cancer cells proliferation and induces apoptosis, but also well prevents metastasis. Importantly, CP-PTX-siCD146-CS nanocomplexes exhibit stronger cytotoxic effects and anti-metastatic effects on MBA-MD-231 breast cancer cells, in comparison with PTX or siCD146 mono-treatment. The current study defines a potential therapeutic strategy for the combined breast cancer treatment and metastasis prevention from a co-delivery perspective. |
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Keywords: | Nanoparticle Drug delivery siRNA Chemotherapy Supramolecular nanocomplex |
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