Hyperinoids A and B,two polycyclic meroterpenoids from Hypericum patulum |
| |
| Institution: | 1. School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China;2. National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;3. Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China;1. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji’nan 250012, China;2. Department of Thoracic Surgery, Qilu Hospital of Shandong University, Ji’nan 250012, China;1. College of Pharmacy, Ji’nan University, Guangzhou 510632, China;2. School of Medicine, Ji’nan University, Guangzhou 510632, China;1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;3. Chinese People’s Liberation Army Logistics Support Force No. 967 Hospital, Dalian 116021, China;1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau 999078, China;2. State Key Laboratory of Drug Research, & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;3. School of Life Science and Technology, Shanghai Tech University, Shanghai 201203, China;4. School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China |
| |
| Abstract: | Hyperinoids A (1) and B (2), two prenylated acylphloroglucinol related meroterpenoids, were isolated from Hypericum patulum. Compound 1 incorporates an unprecedented 11,12-dioxatetracyclo5.4.3.01,7.04,14]tetradecane system, while 2 possesses a unique 10,11-dioxatetracyclo5.3.3.01,7.04,13]tridecane system. Their structures were established by spectroscopic analysis and X-ray crystallographic data. Compounds 1 and 2 were identified as potent NF-κB inhibitors and suppressed the LPS-induced inflammatory responses in RAW 246.7 macrophages and primary mouse BMDM cells |
| |
| Keywords: | Meroterpenoids Hyperinoids A and B Anti-inflammation Guttiferae |
| 本文献已被 维普 ScienceDirect 等数据库收录！ |
|
