Preparation of alumina-carbon composites with phloroglucinol-formaldehyde resin and their application in asymmetric hydrogenation |
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| Institution: | 1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China;2. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China;3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla 92093-0934, United States;1. Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Shanghai 201203, China;2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;4. School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China;1. School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China;2. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, China |
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| Abstract: | To overcome the shortcomings of single component carrier supported platinum (Pt)-based catalysts, herein, we demonstrate the fabrication of alumina combined mesoporous carbon to prepare a series of alumina-carbon composites and their corresponding Pt-based catalysts. The alumina-carbon composites Al@PhFC are synthesized by using phloroglucinol-formaldehyde resin as carbon source and aluminum acetylacetone as the aluminum source. Further, the effect of alumina content on the properties of the composites is investigated. The composites and catalysts are characterized by using XRD, XPS, N2 sorption, and TEM. The Pt/Al@PhFC-1.8 composite with appropriate amounts of alumina, pore diameter, and moderate Pt nanoparticle size, resulted in 99.5% of conversion efficiency and 77.4% of optical selectivity in the asymmetric hydrogenation of ethyl 2-oxo-4-phenylbutanoate (EOPB). Interestingly, this composite can be used more than 20 times without a significant decrease in its performance. |
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| Keywords: | Phloroglucinol-formaldehyde resin Alumina-carbon composite Asymmetric hydrogenation Pt nanoparticles |
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