NIR-triggered drug delivery system based on phospholipid coated ordered mesoporous carbon for synergistic chemo-photothermal therapy of cancer cells |
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| Institution: | 1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;2. Department of Pediatrics, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing 100029, China;3. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China;4. Shanghai Research Institute of Fragrance and Flavor Industry, Shanghai 200232, China;5. School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 200233, China;1. School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China;2. Shenzhen Songgang Hospital, Shenzhen, 518105, China;3. Dongguan Third People’s Hospital, Dongguan, 523326, China;4. Analysis Center, Guangdong Medical University, Zhanjiang, 524023, China;5. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541004, China;1. School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China;2. Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China;3. National Engineering Research Center for Nanotechnology, Shanghai, 200241, PR China |
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| Abstract: | Chemo-photothermal treatment is one of the most efficient strategies for cancer therapy. However, traditional drug carriers without near-infrared absorption capacity need to be loaded with materials behaving photothermal properties, as it results in complicated synthesis process, inefficient photothermal effects and hindered NIR-mediated drug release. Herein we report a facile synthesis of a polyethylene glycol (PEG) linked liposome (PEG-liposomes) coated doxorubicin (DOX)-loaded ordered mesoporous carbon (OMC) nanocomponents (PEG-LIP@OMC/DOX) by simply sonicating DOX and OMC in PEG-liposomes suspensions. The as-obtained PEG-LIP@OMC/DOX exhibits a nanoscale size (600 ± 15 nm), a negative surface potential (−36.70 mV), high drug loading (131.590 mg/g OMC), and excellent photothermal properties. The PEG-LIP@OMC/DOX can deliver loaded DOX to human MCF-7 breast cancer cells (MCF-7) and the cell toxicity viability shows that DOX unloaded PEG-LIP@OMC has no cytotoxicity, confirming the PEG-LIP@OMC itself has excellent biocompatibility. The NIR-triggered release studies demonstrate that this NIR-responsive drug delivery system enables on-demand drug release. Furthermore, cell viability results using human MCF-7 cells demonstrated that the combination of NIR-based hyperthermal therapy and triggered chemotherapy can provide higher therapeutic efficacy than respective monotherapies. With these excellent features, we believe that this phospholipid coating based multifunctional delivery system strategy should promote the application of OMC in nanomedical applications. |
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| Keywords: | Ordered mesoporous carbon Polyethylene glycol linked liposomes Stimuli-responsive drug delivery system NIR-triggered drug delivery Chemo-photothermal therapy |
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