Extracellular vesicles based electrochemical biosensors for detection of cancer cells: A review |
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| Institution: | 1. Department of Clinical Laboratory, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Nanjing 210008, China;2. Department of Clinical Laboratory, Yizheng Hospital of Nanjing Drum Tower Hospital Group, Yizheng 211900, China;3. Department of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China;4. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, National Demonstration Center for Experimental Biomedical Engineering Education (Southeast University), Southeast University, Nanjing 210096, China;5. Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province, Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, China;1. State Key Laboratory of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China;2. Department of Chemistry, University of Michigan, Ann Arbor MI 48109, United States;3. Department of Orthopedic, Nanjing Jinling Hospital, Nanjing 210096, China;1. Nam?k Kemal University, Scientific and Technological Research Center, Tekirda?, Turkey;2. Çanakkale 18 Mart University, Faculty of Engineering, Bioengineering Department, Çanakkale, Turkey;1. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Biotechnology Research Center, Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of medical biotechnology, Faculty of medical sciences, Tarbiat Modares University, Tehran, Iran;4. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran;1. Department of Blood Transfusion, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China;2. Southwest Medical University, Luzhou, Sichuan, China;3. Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China;1. Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai, 200237, China;2. Institute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China;3. School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang, 832000, China |
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| Abstract: | Extracellular vesicles (EVs) derived from cancer cells are considered as ideal biomarker for liquid biopsy in cancer diagnosis, and are stable and abundant. Electrochemical methods for the detection of EVs are preferred over conventional methods such as Western blotting and enzyme-linked immunosorbent assay for their high sensitivity and real-time detection. This article summaries studies proposing the electrochemical methods utilizing immunological and molecular methodologies for detecting EVs derived biomacromolecules such as miRNAs and transmembrane protein for cancer diagnosis. Moreover, the electrochemical detection methods are compared and future prospects for the development of electrochemical methods for EVs detection are concluded. |
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| Keywords: | Cancerous Extracellular vesicles Electrochemical Biosensors Detection |
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