Functionalization of bismuth sulfide nanomaterials for their application in cancer theranostics |
| |
| Institution: | 1. Institute of Bismuth Science, University of Shanghai for Science and Technology, Shanghai 200093, China;2. Cancer Institute, Tongji University School of Medicine, Shanghai 200092, China;1. Institute of Bismuth Science, University of Shanghai for Science and Technology, Shanghai 200093, China;2. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China;1. School of Chemistry, University of Wollongong, Northfields Ave, NSW 2522, Australia;2. Institute of Superconducting and Electronic Materials (ISEM), University of Wollongong, Squires Way, North Wollongong, NSW 2500, Australia;3. Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Northfields Ave, NSW 2522, Australia;4. Centre of Medical and Radiation Physics (CMRP), University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia;5. Radiation Oncology Department, Prince of Wales Hospital, Randwick, High Street, NSW 2031, Australia;1. College of Chemistry, Northeast Normal University, Renmin Street 5268, Changchun 130024, PR China;2. Radiology, the Second Hospital of Jilin University, Changchun 130022, PR China;1. Key Laboratory of Medical Molecular Probes, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003 China;2. Grade 2015 School of Basic Medical Sciences, Xinxiang Medial University, Xinxiang, Henan 453003 China;1. Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, Hubei 430062, China;2. Department of Orthopedics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China;3. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
| |
| Abstract: | Multifunctional bismuth sulfide (Bi2S3) nanomaterials exhibit significant potential as nanomedicines for the diagnosis and treatment of cancer. These nanomaterials act as excellent photothermal agents and radiation sensitizers for the treatment of tumors, and they can also act as contrast agents for computed tomography (CT) imaging, photoacoustic imaging (PA), and other forms of imaging to provide real-time tumor monitoring and testing guidance. Compared with other nanomaterials, Bi2S3 nanomaterials can readily adapt to different applications by virtue of the fact that they can be easily functionalized. However, these nanomaterials have some limitations that cannot be ignored and need to be addressed, such as poor biocompatibility, toxicity, and low chemical stability. It is widely believed that appropriate functionalization of Bi2S3 nanomaterials could remedy such defects and significantly improve performance. This review summarizes the ways in which Bi2S3 nanomaterials can be functionalized and discusses their applications in cancer theranostics over the last few years, focusing particularly on imaging and therapy. We also discuss issues relating to how Bi2S3 nanomaterials can be analyzed, including how we might be able to use these systems to inhibit and treat tumors and how current limitations might be overcome to improve treatment efficacy. Finally, we hope to provide inspiration and guidance as to how we might create a more optimized multifunctional nano-system for the diagnosis and treatment of tumors. |
| |
| Keywords: | Multifunctional nano-system Diagnosis Treatment |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
