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Palladium-catalyzed oxidative homocoupling of 2-arylquinazolinones
Affiliation:1. College of Environment and Public Health, Xiamen Huaxia University, Xiamen 361024, China;2. Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China;1. Henan Key Laboratory of Polyoxometalate Chemistry, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, China;2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, Dalian 116023, China;1. Engineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China;2. Laboratory of Coordination Chemistry (LCC), CNRS & Université de Toulouse (UPS, INP), Toulouse 31077 Cedex 4, France;1. State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing 100190, China;2. Key Laboratory for Environmentally Friendly Chemistry and Application, Department of Chemistry, Xiangtan University, Hunan 411105, China;1. College of Environment and Public Health, Xiamen Huaxia University, Xiamen 361024, China;2. Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China;1. School of Chemical Engineering and Materials, Changzhou Institute of Technology, Changzhou 213032, PR China;2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, PR China
Abstract:Pd-catalyzed oxidative homocoupling of 2-arylquinazolinones was successfully developed for the direct construction of biaryls via Csingle bondH bond activation. New well-defined structure that possessed two quinazolinone units was obtained with high efficiency and atomic economy. The protocols offer an efficient approach to the synthetically useful and functionalized biaryls in good yields using quinazolinone as a directing group.
Keywords:2-Arylquinazolinones  Homocoupling  Palladium-catalyzed
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