Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing |
| |
| Institution: | 1. Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China;2. Research Institute of Sun Yat-sen University in Shenzhen, Shenzhen 518057, China;1. School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China;2. Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen 518057, China;1. School of Materials Science and Engineering, Xi’an University of Technology, Xi’an 710048, China;2. Faculty of Printing, Packaging Engineering and Digital Media Technology, Xi’an University of Technology, Xi’an, Shaanxi 710048, China;1. Dept. of Scienze della Vita e dell’Ambiente, University of Cagliari, Cagliari, Italy;2. Dept. of Drug Chemistry and Technologies, Sapienza, University of Roma, Roma, Italy;3. Dept. of Pharmacy, Pharmaceutical Technology and Parasitology, University of Valencia, Burjassot, Spain;4. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València – Universitat de València, Burjassot, Spain;1. School of Biomedical Engineering, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou, Guangdong 510006, China;2. Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen 518057, China;3. Department of Hematology, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 510006, China;4. Shenzhen Lansi Institute of Artificial Intelligence in Medicine, Shenzhen, Guangdong, China;1. Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China;2. Faculty of Health Sciences, Macao University, Macao, China;3. Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia;1. Polymer Chemistry and Biomaterials Research Group, Faculty of Sciences, Ghent University, Krijgslaan 281, Building S4-bis, B-9000 Ghent, Belgium;2. Magnel Laboratory for Concrete Research, Faculty of Engineering and Architecture, Ghent University, Technologiepark Zwijnaarde 904, B-9052 Ghent, Belgium |
| |
| Abstract: | Baicalin, extracted from traditional Chinese medicine Scutellaria baicalensis Georg, possesses multiple pharmacological activities and has great potential for chronic skin wound repair. However, the poor solubility and lack of suitable vehicles greatly limit its further application. Herein, we proposed a convenient and robust strategy, employing PBS solution as solvent, to enhance the solubility of baicalin. Furthermore, we constructed injectable baicalin/F127 hydrogels to study their application in skin wound treatment. The composition and temperature sensitivity of baicalin/Pluronic® F-127 hydrogels were confirmed by FTIR and rheological testing, respectively. In vitro release measurement indicated that the first order model was best fitted with the release profile of baicalin from hydrogel matrix. Besides, MTT assay, AO/EO staining assay as well as hemolytic activity test revealed the excellent cytocompatibility of baicalin/F127 hydrogels. Antioxidant activity assay demonstrated the cytoprotective activity of baicalin/F127 hydrogels against reactive oxygen species (ROS). Furthermore, the in vivo experiments exhibited the ability of baicalin/F127 hydrogel to accelerate wound healing. In conclusion, this novel injectable baicalin/F127 hydrogel should have bright application for chronic wound treatment. |
| |
| Keywords: | Wound healing Hydrogel Baicalin Antioxidant Injectable |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
