| How do peptide synthetases generate structural diversity? |
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| 引用本文： | Konz D,Marahiel MA. How do peptide synthetases generate structural diversity?[J]. Chemistry & biology, 1999, 6(2): R39-R48. DOI: 10.1016/S1074-5521(99)80002-7 |
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| 作者姓名： | Konz D Marahiel MA |
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| 摘 要： |
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How do peptide synthetases generate structural diversity? |
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| Konz D,Marahiel M A. How do peptide synthetases generate structural diversity?[J]. Chemistry & biology, 1999, 6(2): R39-R48. DOI: 10.1016/S1074-5521(99)80002-7 |
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| Authors: | Konz D Marahiel M A |
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| Affiliation: | Philipps-Universität Marburg, Fachbereich Chemie/Biochemie, Hans-Meerwein-Strasse, D-35032 Marburg, Germany |
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| Abstract: | Many low-molecular-weight peptides of microbial origin are synthesized nonribosomally on large multifunctional proteins, termed peptide synthetases. These enzymes contain repeated building blocks in which several defined domains catalyze specific reactions of peptide synthesis. The order of these domains within the enzyme determines the sequence and structure of the peptide product. |
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