A Practical Synthesis of (S)—(+)—2—(6′—methoxyl—2—naphthyl) propionic Acid |
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作者姓名: | HongZhu BoWANG 等 |
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作者单位: | [1]DepartmentofChemistry,NorthwestUniversity,ShaanXiKeyLaboratoryofPhysico-InorganicChemistry,Xi′an710068 [2]DepartmentofChemistry,NorthwestUniversity,ShaanXiKeyLaboratoryofPhysico-InorganicChemistry,Xi′a |
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摘 要: | A simplified procedure for enantioselective synthesis of (S)-( )-2-(6′-methoxyl-2-naphthyl)propionic acid ((S)-( )-naproxen), starting from (6-methoxy-α-naphthyl)-1-propanone,with D-mannitol as auxiliary catalyzed by SmCl3 in one-pot is described. The yield is 87.5%(ee value 99%).
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关 键 词: | 合成 D-甘露糖醇 (S)-(+)-2-(6′-甲氧基-2-萘基)丙酸 |
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