Optimization of sample transfer in two-dimensional microfluidic separation systems |
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Authors: | Yang Shuang Liu Jikun DeVoe Don L |
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Institution: | Department of Mechanical Engineering, University of Maryland, College Park, MD, USA. |
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Abstract: | Multidimensional microfluidic separation systems combining a first dimension microchannel with an array of parallel second dimension microchannels can suffer from non-uniform sample transfer between the dimensions, sample leakage, and injection plug tailing within the second dimension array. These factors can significantly reduce overall two-dimensional separation performance. In this paper, numerical and analytical models reveal an optimized chip design which combines multidimensional backbiasing and an angled channel geometry to ensure leakage-free and uniform interdimensional sample transfer, while also minimizing injected sample plug lengths. The optimized design is validated experimentally using a multidimensional chip containing five second dimension channels. |
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