Formation of a stable 14-helix in short oligomers of furanoid cis-beta-sugar-amino acid |
| |
| Authors: | Chandrasekhar Srivari Reddy Marepally Srinivasa Jagadeesh Bharatam Prabhakar Anabathula Ramana Rao Mallem H V Jagannadh Bulusu |
| |
| Affiliation: | Indian Institute of Chemical Technology, Hyderabad 500 007, India. srivaric@iict.res.in |
| |
| Abstract: | Oligomers of a new class of sugar amino acids (SAA) using a xylofuranoic acid has been shown to generate a robust 14-helix. The design involved the use of xylofuranose with a cis arrangement between the amine and carboxyl groups to promote the adoption of a 14-helix instead of a mixed 12/10-helix observed in a sugar oligomer using a ribofuranoic acid and beta-Ala. The observation of a stable right-handed 14-helix in a cis-SAA is unprecedented. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
