Calciomics:prediction and analysis of EF-hand calcium binding proteins by protein engineering |
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Authors: | CHEN YanYi XUE ShengHui ZHOU YuBin & YANG Jenny Jie |
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Institution: | CHEN YanYi,XUE ShengHui,ZHOU YuBin & YANG Jenny Jie Department of Chemistry,Georgia State University,Atlanta,GA 30303,USA |
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Abstract: | Ca2+ plays a pivotal role in the physiology and biochemistry of prokaryotic and mammalian organisms.Viruses also utilize the universal Ca2+ signal to create a specific cellular environment to achieve coexistence with the host,and to propagate.In this paper we first describe our development of a grafting approach to understand site-specific Ca2+ binding properties of EF-hand proteins with a helix-loop-helix Ca2+ binding motif,then summarize our prediction and identification of EF-hand Ca2+ binding sites on a... |
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Keywords: | Ca2+ EF-hand calcium binding pockets protein grafting approach Streptococcus pyrogenes Sindbis virus |
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