Influence of PAMAM dendrimers on human red blood cells |
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| Authors: | Domański D M Klajnert B Bryszewska M |
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| Affiliation: | Department of General Biophysics, Institute of Biophysics, University of ?ód?, 12/16 Banacha Street, ?ód? 90-237, Poland. |
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| Abstract: | Polyamidoamine (PAMAM) dendrimers with different concentrations (1 nM-1 mM) (generations 2, 3, and 4) impact on human red blood cell morphology, and membrane integrity is studied. Erythrocyte shape changes from biconcave to echinocytic in dendrimers. Cell aggregation occurs. Polymers cause also concentration- and generation-dependent haemolysis. |
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