Reversed-Phase Liquid Chromatographic Separation, on Cellulose Chiral Stationary Phases, of the Stereoisomers of Methoxytetra-hydronaphthalene Derivatives, New Agonist and Antagonist Ligands for Melatonin Receptors |
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| Authors: | E Lipka C Descamps C Vaccher J P Bonte |
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| Institution: | (1) Laboratoire de Chimie Analytique EA 1043, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille 2-BP 83-3, rue du Pr. Laguesse, 59006 Lille Cedex, France;(2) Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2-BP 83-3, rue du Pr. Laguesse, 59006 Lille Cedex, France |
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| Abstract: | A stereoselective high-performance liquid chromatographic method has been established for chiral separation of melatoninergic derivatives with one or two chiral centers, new agonist and antagonist ligands for melatonin receptors. Reversed-phase separations were performed on cellulose-based chiral stationary phases—tris-3,5-dimethylphenylcarbamate (Chiralcel OD-RH) or tris-methylbenzoate (Chiralcel OJ-R). Water–modifier (methanol or acetonitrile) mixtures in different proportions were used as mobile phases. The effects of organic mobile-phase modifier concentration, temperature, and compound structure were examined. Baseline separation (RS > 1.5) was readily obtained for many of the compounds. |
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| Keywords: | Column liquid chromatography Chiral stationary phases Enantiomer separation Melatoninergic derivatives |
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