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Superparamagnetic nanotraps containing MIP based mimic lipase for biotransformations uses
Authors:Rüstem Keçili  Ayça Atılır Özcan  Arzu Ersöz  Deniz Hür  Adil Denizli  Rıdvan Say
Affiliation:1.Department of Chemistry,Anadolu University,Eskisehir,Turkey;2.Department of Chemistry,Hacettepe University,Ankara,Turkey;3.B?BAM (Plant, Drug and Scientific Researches Center),Anadolu Universitesi,Eskisehir,Turkey
Abstract:The nanoparticle comprises a superparamagnetic iron oxide nanoparticle core conjugated with trimethoxylsilyl propylmethacrylate (TMSPM) and methacryloylamido serine (MASE), methacryloylamido histidine (MAH), methacryloylamido glutamic acid (MAGA) monomers, and p-nitrophenyl palmitate (p-NPP) which is a substrate of lipase as a template molecule, which enables the creation of lipase active region. The resulting hybrid superparamagnetic nanotraps are magnetically separable, highly active, and stable under harsh conditions. In this study, the advantages of high selectivity of molecular imprinting technique have used to get mimic lipase for the synthesis of methyl jasmonate and methyl oleate.
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