| HBx介导的促肝癌作用 |
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| 引用本文： | 穆敬芳,冯辉,胡康洪. HBx介导的促肝癌作用[J]. 武汉大学学报(理学版), 2012, 58(1): 61-67 |
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| 作者姓名： | 穆敬芳 冯辉 胡康洪 |
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| 作者单位： | 中国科学院武汉病毒研究所／病毒学国家重点实验室,湖北武汉,430071 |
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| 基金项目： | 国家自然科学基金，国家“十一五”传染病重大专项基金 |
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| 摘 要： | 乙型肝炎病毒（Hepatitis B virus,HBV）感染是诱发原发性肝癌的主要原因之一.HBV存在4个相互重叠的开放读码框：S,C,P和X区.其中X基因表达的蛋白HBx被认为是诱导肝癌发生的一种多功能致癌蛋白,它可以作用于众多信号通路及细胞因子从而诱发肝癌.本文根据最新的研究,选择其中p53和NF-κB两条信号通路及HBx与表观遗传修饰的相关性进行了探讨,目的在于部分揭示HBV感染诱发肝癌的发病机理.
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| 关 键 词： | 乙型肝炎病毒(HBV) 肝癌(HCC) p53 NF-κB 表观遗传修饰 |
HBx-Mediated Promoting Role in the Development of Hepatocellular Carcinoma |
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| MU Jingfang,FENG Hui,HU Kanghong. HBx-Mediated Promoting Role in the Development of Hepatocellular Carcinoma[J]. JOurnal of Wuhan University:Natural Science Edition, 2012, 58(1): 61-67 |
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| Authors: | MU Jingfang FENG Hui HU Kanghong |
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| Affiliation: | (State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China) |
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| Abstract: | Hepatitis B virus(HBV)caused chronic liver infections is one of the major inducing factors of hepatocellular carcinoma(HCC).The full length viral genome has four overlapping reading frames that consist of S,C,P and X.The X protein of hepatitis B virus(HBx),encoded by the X gene,is a multifunctional protein.It influences a variety of signal transduction pathways and modulates several cytokines,leading to hepatocellular carcinoma.Basing upon the latest studies,this review focuses on the HBx mediated modulation of p53 and NF-κB signal pathway.Additionally,the association between the HBx and the epigenetic modification is discussed,in order to better understand how HBx promotes the development of hepatocellular carcinoma. |
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| Keywords: | hepatitis B virus(HBV) hepatocellular carcinoma(HCC) p53 NF-κB epigenetic modification |
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